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NTCP binder peptide WL4
CAS No.
NTCP binder peptide WL4 ( —— )
Catalog No. M17083 CAS No.
NTCP binder peptide WL4 is a macrocyclic peptide, pan-genotypic inhibitor of HBV cellular entry via targeting the cell-surface receptor for HBV.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameNTCP binder peptide WL4
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NoteResearch use only, not for human use.
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Brief DescriptionNTCP binder peptide WL4 is a macrocyclic peptide, pan-genotypic inhibitor of HBV cellular entry via targeting the cell-surface receptor for HBV.
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DescriptionNTCP binder peptide WL4 is a macrocyclic peptide, pan-genotypic inhibitor of HBV cellular entry via targeting the cell-surface receptor for HBV, sodium taurocholate cotransporting polypeptide (NTCP, Kd=42 nM), reduces HBs antigen levels in culture supernatants with IC50 of 0.66 uM; also inhibits cellular entry by the related hepatitis D virus (HDV), and is active against diverse strains of HBV (including clinically relevant nucleos(t)ide analog-resistant and vaccine escaping strains); exhibitsno inhibition of NTCP-mediated bile acid uptake in contrast to other NTCP-binding HBV entry inhibitors.
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Synonyms——
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PathwayMicrobiology/Virology
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TargetHBV
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RecptorHBV
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Research Area——
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Indication——
Chemical Information
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CAS Number--
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Formula Weight1944.25
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Molecular FormulaC99H122N20O20S
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical NameCyclo-S-Ac-Tyr-Phe-Ile-Ile-ValMe-Gly-Thr-Trp-Thr-Trp-Thr-Trp-Ser-Cys-Thr-NH2
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Passioura T, et al. Cell Chem Biol. 2018 Jul 19;25(7):906-915.e5.
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