NTCP binder peptide WL4 ( —— )

Catalog No. M17083 CAS No.

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Group Booking Get Quotation Bulk Inquiry Add to Cart

Product Name

NTCP binder peptide WL4
Note

Research use only, not for human use.
Brief Description

NTCP binder peptide WL4 is a macrocyclic peptide, pan-genotypic inhibitor of HBV cellular entry via targeting the cell-surface receptor for HBV.
Description

NTCP binder peptide WL4 is a macrocyclic peptide, pan-genotypic inhibitor of HBV cellular entry via targeting the cell-surface receptor for HBV, sodium taurocholate cotransporting polypeptide (NTCP, Kd=42 nM), reduces HBs antigen levels in culture supernatants with IC50 of 0.66 uM; also inhibits cellular entry by the related hepatitis D virus (HDV), and is active against diverse strains of HBV (including clinically relevant nucleos(t)ide analog-resistant and vaccine escaping strains); exhibitsno inhibition of NTCP-mediated bile acid uptake in contrast to other NTCP-binding HBV entry inhibitors.
Synonyms

——
Pathway

Microbiology/Virology
Target

HBV
Recptor

HBV
Research Area

——
Indication

——

CAS Number

--
Formula Weight

1944.25
Molecular Formula

C99H122N20O20S
Purity

>98% (HPLC)
Solubility

——
SMILES

——
Chemical Name

Cyclo-S-Ac-Tyr-Phe-Ile-Ile-ValMe-Gly-Thr-Trp-Thr-Trp-Thr-Trp-Ser-Cys-Thr-NH2

1. Passioura T, et al. Cell Chem Biol. 2018 Jul 19;25(7):906-915.e5.

Calculator

molnova catalog